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003 OCoLC;

005 20240515100435.0;

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035 a| (Sirsi) o170994344;

035 a| (OCoLC)170994344;

049 a| EREE;

050 4 a| QP106.6b| .D97 2006;

100 1 a| Dyson, Ossie F.,e| author.?| UNAUTHORIZED;

245 10 a| ß1 integrins mediate tubule formation induced by supernatants derived from KSHV infected cells /c| by Ossie F. Dyson.;

246 3 a| Beta 1 integrins mediate tubule formation induced by supernatants derived from KSHV infected cells;

246 3 a| Beta one integrins mediate tubule formation induced by supernatants derived from KSHV infected cells;

264 0 c| 2006.;

300 a| x, 70 leaves :b| illustrations (some color) ;c| 28 cm;

336 a| textb| txt2| rdacontent;

337 a| unmediatedb| n2| rdamedia;

338 a| volumeb| nc2| rdacarrier;

502 b| M.S.c| East Carolina Universityd| 2006;

500 a| Presented to the faculty of the Department of Biology.;

500 a| Advisor: Shaw M. Akula;

520 3 a| Angiogenesis is an extremely important process that supports physiological function as well as tumor formation and progression. The four known methods of angiogenesis are sprouting, intussusception, elongation, and incorporation of endothelial cells into endometrial vessels, of which the sprouting form is the most notable. Importantly, angiogenesis is one of the main characteristics of the unique cancers attributed to an infection by Kaposi's sarcoma-associated herpesvirus (KSHV). These cancers include Kaposi's sarcoma, primary effusion lymphoma, and the plasmablastic variant of multicentric Castleman disease. Infection by KSHV regulates angiogenesis via altering the expression of various growth factors. Alternatively, angiogenesis allows for the progression and spread of tumors induced by KSHV infection. Therefore, during KSHV pathogenesis, the angiogenesis process and KSHV infection are synergistic. The role of various signaling pathways and a select number of integrins in directing angiogenesis has previously been demonstrated. However, such signaling and expression of receptors in regulating angiogenesis with respect to KSHV pathogenesis is not fully understood. The current study deciphered the underlying mechanisms that regulate angiogenesis induced by the supernatant derived from KSHV infected cells. Herein, we identified that the PI3K-AKT-BRaf-MEK-ERK signaling-induced [beta] integrins play a crucial role in the angiogenesis process. These findings will aid in a greater understanding of tumor progression and contribute to the development of future cancer therapies.;

504 a| Includes bibliographical references (leaves 42-52).;

650 0 a| Neovascularization.=| ^A291407;

650 0 a| Kaposi's sarcoma.=| ^A708280;

650 0 a| Integrins.=| ^A519075;

650 7 a| Integrins.2| fast0| (OCoLC)fst00975674;

650 7 a| Kaposi's sarcoma.2| fast0| (OCoLC)fst00986150;

650 7 a| Neovascularization.2| fast0| (OCoLC)fst01035916;

655 7 a| Academic theses.2| fast0| (OCoLC)fst01726453;

655 7 a| Academic theses.2| lcgft;

655 7 a| Thèses et écrits académiques.2| rvmgf0| (CaQQLa)RVMGF-000001173;

700 1 a| Akula, Shaw M.,e| degree supervisor.=| ^A1406820;

710 2 a| East Carolina University.b| Department of Biology.=| ^A637467;

856 41 z| Access via ScholarShipu| http://hdl.handle.net/10342/11972;

949 a| Click on web addressw| asish| joyner101;

949 a| Click on web addressw| asish| hsl111;

994 a| C0b| ERE;

596 a| 1 4;

998 a| 1093219;

999 a| ASK AT SPECIAL COLLECTIONS DESKw| ASISc| 1i| MQ1936419l| JSCJTHDm| JOYNERr| Ys| Yt| JSCJTHDu| 9/12/2007x| ETDz| JSPECCOLLo| .STAFF. 0;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 1093219-3001l| JNETm| JOYNERr| Ys| Yt| JNE3ETDu| 5/15/2024x| ETDz| JERESOURCE;

999 a| CLICK ON WEB ADDRESSw| ASISc| 1i| 1093219-4001l| HSLELECm| HSLr| Ys| Yt| HEETDu| 5/15/2024x| ETDz| HERESOURCE;

ß1 integrins mediate tubule formation induced by supernatants derived from KSHV infected cells / by Ossie F. Dyson.

Author/creator	Dyson, Ossie F. author.
Other author	Akula, Shaw M., degree supervisor.
Other author	East Carolina University. Department of Biology.
Format	Theses and dissertations
Production	2006.
Description	x, 70 leaves : illustrations (some color) ; 28 cm
Supplemental Content	Access via ScholarShip
Subjects	Neovascularization. Kaposi's sarcoma. Integrins.

Variant title	Beta 1 integrins mediate tubule formation induced by supernatants derived from KSHV infected cells
Variant title	Beta one integrins mediate tubule formation induced by supernatants derived from KSHV infected cells
Summary	Angiogenesis is an extremely important process that supports physiological function as well as tumor formation and progression. The four known methods of angiogenesis are sprouting, intussusception, elongation, and incorporation of endothelial cells into endometrial vessels, of which the sprouting form is the most notable. Importantly, angiogenesis is one of the main characteristics of the unique cancers attributed to an infection by Kaposi's sarcoma-associated herpesvirus (KSHV). These cancers include Kaposi's sarcoma, primary effusion lymphoma, and the plasmablastic variant of multicentric Castleman disease. Infection by KSHV regulates angiogenesis via altering the expression of various growth factors. Alternatively, angiogenesis allows for the progression and spread of tumors induced by KSHV infection. Therefore, during KSHV pathogenesis, the angiogenesis process and KSHV infection are synergistic. The role of various signaling pathways and a select number of integrins in directing angiogenesis has previously been demonstrated. However, such signaling and expression of receptors in regulating angiogenesis with respect to KSHV pathogenesis is not fully understood. The current study deciphered the underlying mechanisms that regulate angiogenesis induced by the supernatant derived from KSHV infected cells. Herein, we identified that the PI3K-AKT-BRaf-MEK-ERK signaling-induced [beta] integrins play a crucial role in the angiogenesis process. These findings will aid in a greater understanding of tumor progression and contribute to the development of future cancer therapies.
General note	Presented to the faculty of the Department of Biology.
General note	Advisor: Shaw M. Akula
Dissertation note	M.S. East Carolina University 2006
Bibliography note	Includes bibliographical references (leaves 42-52).
Genre/form	Academic theses.
Genre/form	Academic theses.
Genre/form	Thèses et écrits académiques.

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ß1 integrins mediate tubule formation induced by supernatants derived from KSHV infected cells / by Ossie F. Dyson.

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