LEADER 03480cam 2200565 i 4500001 on1332541685 003 OCoLC 005 20231102105607.0 006 m o d 007 cr unu|||||||| 008 220623s2022 ncua obm 000 0 eng d 035 (Sirsi) o1332541685 035 (OCoLC)1332541685 040 ERE |beng |erda |cERE |dOCLCQ |dOCLCF |dERE |dUtOrBLW 049 EREE 090 RC386.6.E43 100 1 Wang, Lana, |eauthor. |?UNAUTHORIZED 245 10 Functional connectivity analysis of visually evoked ERPs for mild cognitive impairment / |cby Lana Wang. 264 1 [Greenville, N.C.] : |b[East Carolina University], |c2022. 300 1 online resource (79 pages) : |billustrations (some color) 336 text |btxt |2rdacontent 337 computer |bc |2rdamedia 338 online resource |bcr |2rdacarrier 347 text file 347 |bPDF 347 |c2.271 MB 538 System requirements: Adobe Reader. 538 Mode of access: World Wide Web. 502 |bM.S. |cEast Carolina University |d2022 500 Presented to the Faculty of the Department of Engineering 500 Advisor: Sunghan Kim 500 Title from PDF t.p. (viewed October 23, 2023). 520 3 Mild cognitive impairment (MCI) is considered as the early stage of Alzheimer's disease, characterized as mild memory loss. Using electroencephalogram (EEG) data, a novel method of functional connectivity (FC) analysis can be used to detect MCI before memory is significantly impaired allowing for preventative measures to be taken. FC examines interactions between EEG channels to grant insight on underlying neural networks and can also allow for an examination of the effects of MCI on these neural networks. The FC method of weighted phase lag index (wPLI) provided insight on the link between the pathology of Alzheimer's disease and cognitive loss. wPLI was analyzed per frequency band (theta, alpha, mu, beta) and by channel combination groups (intra-hemispheric short, intra-hemispheric long, inter-hemispheric short, inter-hemispheric long, transverse). MCI was found to have a statistically significant lower [delta]wPLIP300 compared to normal controls in the mu intra-hemispheric short (p = 0.0286), mu intra-hemispheric long (p = 0.0477), mu inter-hemispheric short (p = 0.0018) and the alpha intra-hemispheric short (p = 0.0423). Results indicate a possible deficiency in the dorsal visual processing pathway among MCI subjects as well as an unbalanced coordination between the two hemispheres. 504 Includes bibliographical references. 650 0 Electroencephalography. |=^A1408 650 0 Mild cognitive impairment. |=^A1385612 650 0 Alzheimer's disease. |=^A12721 653 event related potentials 653 functional connectivity 655 7 Academic theses. |2fast |0(OCoLC)fst01726453 655 7 Academic theses. |2lcgft 700 1 Kim, Sunghan, |d1975- |edegree supervisor. |=^A1434862 710 2 East Carolina University. |bDepartment of Engineering. |=^A1231592 856 40 |uhttp://hdl.handle.net/10342/10654 |zAccess via ScholarShip 949 |owjh 994 C0 |bERE 596 1 4 998 5831713