||The foundation of NICE guidance is the synthesis of evidence primarily through the process of systematic reviewing and, if appropriate, modelling and cost effectiveness decision analysis. The results of these analyses are then discussed by independent committees. These committees include NHS staff, healthcare professionals, social care practitioners, commissioners and providers of care, patients, service users and carers, industry and academics. Stakeholders have the opportunity to comment on draft recommendations before they are finalised. Not only does this process explicitly describe the evidence base, it also identifies where there are gaps, uncertainties or conflicts in the existing evidence. Many of these uncertainties, although interesting to resolve, are unlikely to affect people's care or NICE's ability to produce guidance. However, if these uncertainties may have an effect on NICE's recommendations it is important for NICE to liaise with the research community to ensure they are addressed. NICE does this by making recommendations for research, which are communicated to researchers and funders. At the time guidance is issued, NICE's staff and committees have a thorough understanding of the current evidence and valuable insights into uncertainties that need to be resolved. It is important that these are capitalised on. To undertake its national role effectively, NICE needs to ensure that: 1. the process of developing the research recommendations is robust, transparent and involves stakeholders2. we identify research priorities3. we make all research recommendations clearly identifiable in the guidance4. the research recommendations provide the information necessary to support research commissioning5. the research recommendations are available to researchers and funders by promoting them (for example through the research recommendations database)6. the research recommendations are relevant to current practice7. we communicate well with the research community. This process and methods guide has been developed to help guidance-producing centres make research recommendations. It describes a step-by-step approach to identifying uncertainties, formulating research recommendations and research questions, prioritising them and communicating them to the NICE Science Policy and Research (SP&R) team, researchers and funders. It has been developed based on the SP&R team's interactions with research funders and researchers, as well as with guidance developers.