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Animal models for microbiome research : advancing basic and translational science: proceedings of a workshop / Joe Alper, Lida Anestidou, and Jenna Ogilvie, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Academies of Sciences, Engineering, and Medicine.

Author/creator Alper, Joe rapporteur.
Format Electronic and Book
Publication Info Washington, DC : National Academies Press, [2018]
Description1 online resource (1 PDF file (xv, 98 pages)) : illustrations
Supplemental Content Direct link to resource
Subject(s)
Other author/creatorAnestidou, Lida, 1965- rapporteur.
Other author/creatorOgilvie, Jenna, rapporteur.
Other author/creatorNational Academies of Sciences, Engineering, and Medicine (U.S.). Division on Earth and Life Studies, issuing body.
Other author/creatorInstitute for Laboratory Animal Research (U.S.). Roundtable on Science and Welfare in Laboratory Animal Use, issuing body.
Other author/creatorAnimal Models for Microbiome Research: Advancing Basic and Translational Science (Workshop) (2016 : Washington, D.C.)
Contents Introduction -- A trans-kingdom perspective on animal models and microbiome research -- Non-rodent models for microbiome research -- Modeling human microbiota in animal systems -- Experimental reproducibility using gnotobiotic animal models -- Establishing and evolving gnotobiotic facilities -- Reflections on the workshop.
Summary The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop.
Bibliography noteIncludes bibliographical references.
Funding informationThis project was supported by the American Veterinary Medical Association; Covance Laboratories, Inc.; Genentech; GlaxoSmithKline; Massachusetts General Hospital; Merck; National Primate Research Centers; National Science Foundation; Novartis; University of California, Davis; University of Michigan; University of Pittsburgh; University of Washington; U.S. Food and Drug Administration; and Yale University. Funding for this conference was made possible, in part, by the U.S. Food and Drug Administration through grant 5 R13 FD 005298-02. The views expressed in written conference materials or publications and by speakers or moderators do not necessarily reflect the official policies of the U.S. Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the U.S. government. This material is based on work supported by the National Science Foundation under Grant No. IOS-1639899. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.
Source of descriptionOnline resource; title from PDF title page (viewed September 7, 2018).
Issued in other formPrint version: Alper, Joe. Animal models for microbiome research. Washington, D.C. : National Academies Press, [2018] 9780309463881
ISBN9780309463898 (electronic)
ISBN0309463890 (electronic)
ISBN(paperback)
ISBN(paperback)
Standard identifier# 10.17226/24858

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