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Biomarkers of neuroinflammation : proceedings of a workshop / Lisa Bain, Noam I. Keren, and Sheena M. Posey Norris, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Health and Medicine Division.

Author/creator Bain, Lisa J. rapporteur.
Format Electronic and Book
Publication Info Washington, DC : The National Academies Press, [2018]
Copyright Notice ©2018
Description1 online resource (xii, 77 pages) : color illustrations.
Supplemental Content Direct link to resource
Other author/creatorKeren, Noam I., rapporteur.
Other author/creatorNorris, Sheena M. Posey, rapporteur.
Other author/creatorNational Academies of Sciences, Engineering, and Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders.
Other author/creatorBiomarkers of Inflammation (Workshop) (2017 : Washington, D.C.), author.
Series A consensus study report of the National Academies of Sciences, Engineering, Medicine
Consensus study report. ^A1363519
Contents Introduction and overview -- Biomarkers of neuroinflammation: challenges and potential opportunities -- State of the science of neuroinflammation in central nervous system disorders -- Neuroinflammation in disease -- Neuroimaging biomarkers: current initiatives and opportunities -- Cerebrospinal fluid and other fluid biomarkers: current initiatives and opportunities -- Potential mechanisms for moving forward -- Appendixes.
Abstract "Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop"--Publisher's description.
Bibliography noteIncludes bibliographical references (pages 57-62).
Source of descriptionOnline resource; title from PDF title page (National Academies Press, viewed February 22, 2018).
Issued in other formPrint version: National Academies of Sciences, Engineering, and Medicine. Biomarkers of Neuroinflammation : Proceedings of a Workshop. Washington, D.C. : National Academies Press, ©2018 9780309463652
Standard identifier# 10.17226/24854
Stock number00017961

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