LEADER 04613cam 2200517Ii 4500001 ocn857590014 003 OCoLC 005 20131120121715.0 006 m o d 007 cr bn||||||||| 008 130904s2013 ncua ob 000 0 eng d 035 (Sirsi) o857590014 035 (OCoLC)857590014 040 ERE |erda |cERE |dERE |dUtOrBLW 049 EREE 090 QD181.P8 100 1 Vezzu, Dileep Atchyuth Kumar, |eauthor. |?UNAUTHORIZED 245 10 Synthesis, structure, photophysics, and biological activity of platinum (II) complexes / |cby Dileep Atchyuth Kumar Vezzu. 246 1 |ititle from abstract pageSynthesis, structure, photophysics, and biological activity of cyclometalated platinum (II) complexes 264 1 [Greenville, N.C.] : |b[East Carolina University], |c2013. 300 291 pages : |billustrations (some color) 336 text |btxt |2rdacontent 337 computer |bc |2rdamedia 338 online resource |bcr |2rdacarrier 347 text file |bPDF |c11.77Mb |2rda 538 System requirements: Adobe Reader. 538 Mode of access: World Wide Web. 502 |bPh.D. |cEast Carolina University |d2013. 500 Presented to the faculty of the Interdisciplinary Doctoral Program in Biological Sciences. 500 Advisor: Shouquan Huo. 500 Title from PDF t.p. (viewed October 1, 2013). 520 3 The synthesis, structure, and photophysical properties of luminescent platinum (II) complexes with different coordination patterns, (C^C*N^N), (N^C*N), (N^N*C) and (N^N^C) are reported, where "C^N or N^N" denotes a bidentate coordination to the platinum to form a five-membered metallacycle and "C*N" denotes a bidentate coordination to the platinum to form a six-membered metallacycle. Sixteen cyclometalated platinum complexes have been synthesized with different coordination patterns, which include six complexes with tridentate N^C*N cyclometalating ligands (13, 14, 15, 16, 17, and 18), five complexes with N^N*C cyclometalating ligands (19a, 19b, 20a, 20b, and 24), three complexes with N^N^C cyclometalating ligands (21a, 21b, and 29) and two complexes with tetradentate C^C*N^N cyclometalating ligands (33 and 34). The structures of the platinum complexes 13, 15, 16, 18, 19a, 19b, 20a, 21a, 21b, 24, 29, 33, and 39 were determined by single crystal X-ray diffraction. In platinum complexes with five-six membered metallacycle (15, 16, 18, 19a, 19b, 20a, 24, and 39), the square geometry of the complexes is improved when compared to that of platinum complexes with five-five membered metallacycle as the biting angle is increased. The tetradentate coordination (C^C*N^N), square planar geometry of complex 33 are revealed from its X-ray crystal structure. The DFT calculations have been carried out on complexes 13, 14, 15, 16, 17, 18, 33, and 34 to examine the molecular orbital character of the complexes, which are used in interpreting the electronic spectra of the complexes. The photophysical properties of the platinum complexes were studied and a majority of the complexes were highly emissive in solution at room temperature. Complex 13 exhibited the highest quantum yield (65%) among all of the complexes. Self quenching was not observed in a majority of the platinum complexes at lower concentrations. The cytotoxicity (IC₅₀) of the complexes in three lung cancerous cell lines and one prostate cancer cell line were determined by MTT assay. The toxic platinum complexes induced the cell death by triggering apoptosis. The interactions of the platinum complexes with plasmid and calf thymus DNA were studied. Activation of caspase -7, PARP, and p53 were also observed in RV1 and HCC827 cell lines when treated with platinum complexes. Complexes 35, 37 and 38 were more potent than the clinically approved drug, cis-platin. 504 Includes bibliographical references. 650 0 Platinum compounds. |=^A827427 653 Chemistry 653 Inorganic chemistry 653 Oncology 700 1 Huo, Shouquan, |edegree supervisor. |?UNAUTHORIZED 710 2 East Carolina University. |bInterdisciplinary Doctoral Program in Biological Sciences. |?UNAUTHORIZED 856 40 |zAccess via ScholarShip |uhttp://hdl.handle.net/10342/4260 949 |ojgml 994 C0 |bERE 596 1 4 998 3362001