||Peripheral arterial disease (PAD) is a highly prevalent disorder that is associated with significant cardiovascular morbidity and mortality. Despite its prevalence and severity, PAD is underdiagnosed and undertreated in primary care practice. In order to address this public health crisis, the American College of Cardiology and the American Heart Association, in collaboration with the nation's major vascular societies, released new practice guidelines for the management of patients with PAD. In this video program, Dr. Alain Drooz, a leading vascular specialist, explains how to easily apply the new guidelines for PAD in clinical practice. He reviews the differential diagnosis of PAD, provides strategies for risk reduction and secondary prevention, outlines primary treatment of symptoms of intermittent claudication, and explains when to refer a patient with PAD to a vascular specialist. Practical application of the guidelines is further enhanced by the inclusion of two cases of actual patients with PAD and treatment algorithms for PAD organized by disease severity.