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| Contents |
Major histocompatibility complex class II -- Genetic susceptibility and class III complement genes -- Constitutive genes and lupus -- Genetics of lupus in mice -- B-cell tolerance and autoimmunity - Dendritic cells in SLE -- T-cells and systemic lupus erythematosus -- B-lymphocyte biology in SLE -- Polymorphonuclear and endothelial cells -- Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T-cells of patients with SLE -- Cell cycle regulation and systemic lupus erythematosus -- The role of reactive nitrogen and oxygen intermediates in system lupus erythematosus -- Origins of antinuclear antibodies -- Anti-DNA antibodies: structure, regulation and pathogenicity -- Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis -- Antihistone and antispliceosomal antibodies -- Toll-like receptors in SLE -- Interferon-alpha in systemic lupus erythematosus -- Immune complexes in systemic lupus erythematosus -- Complement and tissue injury in SLE -- Humoral pathogenesis: Fc[gamma] receptors in autoimmunity and end-organ damage -- Drug-induced lupus mechanisms -- Gender and age in lupus -- Roles for infections in systemic lupus erythematosus pathogenesis -- Systemic lupus erythematosus in domestic animals -- Pathogenesis of lupus nephritis -- Tissue injury and the skin -- Neuropsychiatric systemic lupus erythematosus: mechanisms of injury -- Atherosclerosis and tissue injury in systemic lupus erythematosus -- The clinical presentation of systemic lupus erythematosus -- Neonatal lupus -- SLE in children -- Drug-induced disease -- Laboratory evaluation of patients with systemic lupus erythematosus -- Pregnancy and reproductive concerns in systemic lupus erythematosus -- Epidemiology of systemic lupus erythematosus -- Monitoring disease activity -- Incomplete lupus erythematosus -- Design of clinical trials for SLE -- The nervous system and lupus -- Skin -- Kidney -- Heart -- Vasculitis -- Lung -- Gastrointestinal: liver -- Gastrointestinal: nonhepatic -- Cellular hematology -- Musculoskeletal system: articular disease, bone metabolism -- Antiphospholipid syndrome: pathogenesis -- Endothelial cell damage and atherosclerosis -- Laboratory testing for antiphospholipid syndrome -- Clinical presentation of antiphospholipid syndrome -- Pregnancy and antiphospholipid syndrome -- Treatment of antiphospholipid syndrome -- Corticosteroid and nonsteroidal anti-inflammatory drug use in systemic lupus erythematosus -- Antimalarials and SLE -- Systemic lupus erythematosus: cytotoxic agents -- Biologic agents in the treatment of systemic lupus erythematosus. |
| Local note | Laupus-WCP |
| General note | Previous ed.: 2004. |
| Bibliography note | Includes bibliographical references and index. |
| ISBN | 9780123749949 (hbk.) |
| ISBN | 0123749948 (hbk.) |
